Rose Exctracts and In-Vitro Inhibition of SARS-CoV-2 Spike: The Ace-2 Interaction

Abstract Objective The study was performed to evaluate the novel potential of red rose extract inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro. Methods ACE2 receptors were His-labelled, and studied by chemiluminescence after addition anti-His HRP substrate. inhibition assessed a dose-dependent sequence. Results 50% inhibitory concentration observed at 0.75 percent v/v extract, 90% seen about 1.8 v/v. Steam inhalation or nebulization could be simple methods delivering extracts lower respiratory tract pulmonary tissues. Conclusion Rose have for vitro, which add beneficial effects Covid-19 treatment. Further tests need their therapeutic benefits vivo.